Systems
The DIANT® LiFT – High Throughput Nanoparticle Manufacturing
About the DIANT® LiFT (With NanoFlowSizer™)
The DIANT® LiFT is our commercial lipid nanoparticle production system, which can scale-up processes from our benchtop DIANT® LARU system for the continuous production of lipid and polymer-based liquid-injectable nanoparticle pharmaceutical products. With inline dilution, drug loading, and nanoparticle modification, the LiFT’s continuous processing offers extensive benefits over traditional batch processing.
As the exclusive distributor of the NanoFlowSizer™ in the United States, DIANT’s systems work with InProcess-LSP’s unique particle size analyzer technology to non-invasively characterize nanoparticles inline.
DIANT® LiFT Specifications
The DIANT® LiFT, our production-ready manufacturing skid, comes equipped with:
- DIANT® Jet technology for high throughput
- Continuous particle size analysis through Process Analytical Technology (PAT)
- Integrated, inline particle size control and monitoring with InProcess-LSP
- NanoFlowSizer™, SR-DLS
- Automatic particle size control
- Real-time particle monitoring
- Fast response (~6 seconds per measurement)
- Hybrid or integrated system
- Explosion-proof-rated design
- Capacity options from 0.8 LPM to:
-
DIANT® LiFT – 2 LPM maximum
-
DIANT® LiFT HP – 20 LPM maximum
-
- 21 CFR-compliant software
- Continuous or batch operation
- Commercial GMP-compliant manufacturing of lipid nanoparticles (LNPs), liposomes, nucleic acid/lipid complexes, polymeric micelles, suspensions, and emulsions
DIANT® LiFT Add-Ons and Continuous Processing Systems
Optional add-ons that are available for the DIANT® LiFT include:
- Customized PAT integration
- Particle size analyzer
- pH monitor/probes
- Conductivity
- Temperature control – Control the temperature of your sample at each stage with the water circulator, sold separately
DIANT® LiFT + IEM
The DIANT® IEM is a continuous processing system for the controlled modification of pre-formed vesicular nanoparticles:
- Intravesicular aqueous modifications – small molecules like liposomes can be actively loaded to promote drug encapsulation
- Extravesicular surface modifications – capabilities include adding polymeric coating and active drug moieties
The IEM system can:
- Perform one or several simultaneous nanoparticle modifications as a continuous process
- PEGylate particles, including LNPs, polymeric micelles, and others
- Decorate particles
- Manage growth kinetics
- Salt loading for liposomes
- Surface deposition for LNPs
- Perform PAT – inline UV-Vis with model prediction (optional & customizable)
- Sense pressure, conductivity, and temperature
- Perform inline heat exchange and mixing
- Perform inline bioburden reduction filtration at collection
- Perform inline, single-pass concentration